Compositions and methods for treating mycobacterial infections

Université Libre de Bruxelles - Réseau LIEU - 06/03/2020

Description

We have surprisingly discovered that new specific combinations of a first agent preferably selected from glycopeptides and a second agent preferably selected from lipase inhibitors display significant mycobacteriostatic and/or mycobactericidal properties, and thus allows mycobacterial infections to be treated. The present inventors have also surprisingly discovered that such specific combinations display significant mycobacteriostatic and/or mycobactericidal properties towards multidrug-resistant or extensively drug-resistant mycobacterial strains and thus allow multidrug-resistant or extensively drug-resistant mycobacterial infections to be treated, and provides a new array of combination treatments that can be used as an alternative to established therapies. We have also surprisingly discovered that such specific combinations can be used for screening new compounds useful for the treatment of mycobacterial infections or for treating MDR or XDR mycobacterial infections.

Benefits

New strategies against all mycobacteria including MDR and XDR-TB; Successful in vitro antimycobacterial activity.

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