Offres de technologies

Endoscopic intraluminal device for morbid obesity and diabetes treatment

The technology is an endoscopic intraluminal device implanted temporarily. The structure of the device allows a double action by restricting the quantity ingested (intra gastric balloon effect) and also limiting bolus absorption (duodeno-jejunal bypass liner effect). The device implantation is suitable for ambulatory surgery, which reduces duration of hospitalization and health care costs for patients....

Room of illumination for raman spectroscopy

Analytical Quality Control aims at guaranteeing the parameters, identity, purity and concentration of the molecules of interest. In hospital pharmacies, manufactured products can be expensive or need specific precautions of use (e.g. chemotherapies). In general, the devices used for quality control present many drawbacks in terms of waste of time and materials, of samples loss of integrity or of exposure of medical staff to hazardous compounds. The in...

Composé destiné au traitement des douleurs abdominales fonctionnelles

La technologie proposée est un nouveau traitement des douleurs abdominales fonctionnelles. Il a été démontré que l’utilisation du composé permettrait la prévention et le traitement de ces douleurs chez l’adulte, mais également chez l’enfant. Le produit a déjà été administré à deux enfants qui présentaient ce type de douleur, sans qu’aucun élément pathologique particulier n...

Utilisation du cannabis médical (sativex®) dans la dégénérescence neuronale de l’oesophage (achalasie)

L’achalasie est une dégénérescence inflammatoire neuronale causant des troubles de la motilité de l’oesophage (dysphagie, régurgitations, perte de poids importante). Aucun traitement médicamenteux (myorelaxants) n’a prouvé son efficacité et les alternatives thérapeutiques sont invasives et peu efficaces. Nous proposons une nouvelle indication pour le cannabis médical (Sativex ®) ...

Device for measuring the length of a stenosis

Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) affect around 1.6 million Americans and represent a sales market worth $5.6 billion worldwide. Intestinal inflammation often results in stenosis, for which a classic treatment is surgical resection. However, surgical resection is a drastic option ; if the stenosis is located on a zone accessible to endoscopy, it can be treated alternatively by dilatation, using an endoscope coupled...

Method for increasing the pool of ngn3+ endocrine progenitor cells and pancreatic endocrine cell mass

Controlling glycemia with insulinotherapy is a challenge that diabetic patients face every day. Moreover, insulinotherapy is not a curative therapy by any means. This line of treatment is only palliative and presents many limitations for the fine control of blood sugar levels. Uncontrolled blood sugar levels can result in serious damages to the eyes, nerves and kidneys of diabetic patients. However, pancreatic islets transplantation provides an altern...

New biodegradable anti-migration intestinal stent

In the US, nearly 1,5 million patients suffer from Crohn’s disease. The most common complication is digestive stenosis (50% of patients). If the stenosis measures less than 5 centimeters, an endoscopic dilatation is possible. However, it is associated with relapse rates of 30 to 50 % at 1-3 years. In this case, the patient undergoes another endoscopic dilatation or sometimes a bowel resection. The use of covered expandable metallic prostheses (used...

Endovascular scissors for aortic fenestration

Ciseaux de fenestration endovasculaires

La dissection de l’aorte thoraco-abdominale est une pathologie grave, engageant le pronostic vital des patients à court et long terme. L’incidence est d’environ 1% avec un taux de mortalité de 50% dans les 48 premières heures. Elle se caractérise par une déchirure au niveau de la paroi interne de l’aorte permettant au sang de s’engouffrer entre les feuillets superposés constituant...

Compounds for the treatment of mitochondrial diseases

The present invention relates to the isolation and development of drugs to treat mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as NARP syndrome. NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) is a maternally transmitted hereditary syndrome characterized by retarded development, and accompanied by retinitis pigmentosa (RP), dementia, ataxia, proximal neurological muscle weakness ...

Enabeling/facilitating trans-cutaneous delivery of active material

Efficient trans-cutaneous delivery of active molecules is still a challenge due to the nature itself of the dermal tissue. The permeabibility of therapeutic agents can be improved by permeability agents but most of the induced delivery mechanisms induce irreversible skin alterations. We present here an original strategy consisting in using the active molecule itself to parcicipate into ist own trans-cutaneous transport, while protecting solubilizing a...

Low energy consumption backery oven

Bread baking requires a large quantity of energy – roughly 2 to 5 Mjoules /kg that is 2 to 3 times higher than the energy required for the same mass of a food product in the form of canned food for example. Furthermore food habits are changing in the world : we see in most European countries a decreasing consumption of bakery products at home while the consumption of bakery products outside home increases significantly. This market trend is suppor...

Nanpoparticles synthesis

Nanopowders are of great interest due to their specific properties. There are various production routes but quality of the powders ie composition, size and size distribution, crystallography… may vary from one another.

Natural compounds activating sirt1 for the cellulite treatment

The sirtuin family concerns nuclear NAD+ dependant deacetylases, playing an important role in deacetylation of histones. Sirtuin 1 is the best known situin. It is involved in an important number of metabolic processes. It has several target as p53, FoxO, PPAR gamma, PGC1 alpha, UCP2, LXR and Ku70, key regulating proteins in cell functions. Sirt1 has a global anti-aging effect. The Sirt1 expression decreases along the lifetime. Sirt1 has also a rol...

One step in-situ graphene oxide reduction in composite

It is well known that electrical or thermal properties of graphene are of importance in composites for applications like anti-static composites, biomedical, organic electronics, sensors… but the mixing of graphene in polymers is not easy. It has thus been proposed to mix graphene oxide (GO), a graphene derivative which by contrast to neat graphene can be easily processed, with the organic matrix and then to reduce it. This reduction step is performe...

Packaging with two-color visual effect for decoration or identification

Packaging constitutes an important vehicle for the image of a brand. We propose to produce thin films having bichromatic properties that can be deposited on any transparent or translucent substrate (glass, ceramic, polymer .. ) , the two-color effect being not dependent on the angle of observation.

Protein involved in dna replication, and modulation of its activity

Although DNA replication is a vital process for cell growth and its mechanism is highly conserved, recent studies also reveal significant diversity in origin structure, assembly of pre-replication complex (pre-RC) and regulation of replication initiation along evolutionary lines. It is crucial to maintain genomic integrity in eukaryotic cells. During DNA replication, errors in pre-RC assembly often result in substantial changes in the amount of genet...

Optimized plant growth chamber

Fully integrated plant growth chambers with LED lighting system and climate control   Technology Full specifications for climate-controlled growth chambers and plant shelves including suitable LED lighting Perfectly adapted to Arabidopsis thali...

Optomechanical thz sensor

The most advanced commercial technologies for the detection of Terahertz (THz) and far infrared electromagnetic waves have major drawbacks : bolometers work at very low temperatures (4 Kelvin), while Golay cells are notoriously slow (20 Hz). Furtherm...

Picometer precision spectral tuning of micro and nanophotonic resonators

State-of-the-art nanofabrication tools (electronic beam lithography, reactive ion etching) can nowadays reach a few nanometer precision. This is still not accurate enough in optical applications such as metrology where collective behavior of resonato...

Java implementation of rpl, ipv6 routing protocol for low power and lossy networks

This software is a Java implementation of the Routing Protocol for Low-Power and Lossy Networks (RPL) [RFC6550], intended for performance evaluation by way of network simulations. RPL is a protocol for routing in low-power lossy networks, also often called “sensor networks”. While this protocol implementation is intended for use with the network simulator ns2, it is independent (contains no code from ns2) and can be adapted to run also on any JVM...

Epitaxie dans un réacteur pecvd standard a basse température (200°c)

Les procédés de fabrication de couches minces pour les dépôts grande surface et la réalisation des composants pour la microélectronique ont suivi des voies très différentes jusqu’à présent. Pour les semi-conducteurs, les matériaux doivent généralement être cristallins, le plus parfaits possible; leurs procédés de fabrication nécessitent souvent des conditions expérimentales ext...

Gift: new improved platelet lysates for: neuroprotection, neurorestoration and neurogenesis

Platelets constitute abundant, natural, readily accessible sources of physiological mixtures of numerous growth factors (GFs) with proven effects on cell survival and proliferation. Platelet lysates (PL) are already used in several fields of human r...

Gift : nouveaux lysats plaquettaires améliorés pour la neuroprotection, neurorestauration et neurogenèse

Les plaquettes constituent une source abondante, naturelle, facilement accessible d’un mélange physiologique contenant de nombreux facteurs de croissance, avec des effets prouvés sur la survie et la prolifération cellulaire.Le lysat plaquettaire (LP...

High purity hydrogen production from steel slags

Hydrogen can be produced in several ways. However, known methods all exhibit drawbacks. They are either expensive, high energy consuming or produce greenhouse gases. Hydrogen purity is also paramount. If hydrogen is to be used in hydrogen fuel cells, high degree of purity is indeed critical as even trace amounts of impurities present in the hydrogen can poison the anode, membrane, and cathode of the fuel cell resulting in performance drops. These pa...

Method for synthetizing 2-acetyl-1-pyrroline and the stable precursor thereof, optionally isotopically marked

The present invention relates to a method for synthesizing 2-acetyl-1-pyrroline (2AP) and of ketal derivatives of 2AP as stable precursors in flavoring compositions. 2AP is a volatile molecule which smells of popcorn, basmati rice and toasted bread. It is one of the aromatic compounds of perfume rice, i.e. rice varieties from restricted genetic populations that cannot be cultivated outside their original area....

New conducting polymer for lithium-ion batteries

CONTEXT In lithium ion batteries, the electrode is often designed by the use of an active electrochemical material (LCO, NCA, NMC, LMO, LFP), a conductive agent (Carbon black) and a binder (PVDF). In recent years, batteries having a high energy density have come to be required and research have been conducted on conducting polymers such as polyaniline (PANi), polythiophene or polypyrrole as active materials or binders....

Ispinach: an optimized fluorogenic rna aptamer

The recent development of new fluorogenic dyes and the concomitant isolation of specific RNA aptamers offer the possibility to monitor in real-time the synthesis of a specific RNA both in vitro and in vivo. Among this new generation of dyes, the 3,5-difluoro-4-hydroxybenzylidene imidazolinone (DFHBI), a commercially available dye mimicking the natural fluorophore of the green fluorescent protein, proved to be particularly well suited for live-cell ima...

Cd146 mab & cancer - igg monoclonal antibodies targeting hu scd146 inhibiting tumor angiogenesis and growth

BACKGROUND In the field of anti-tumor therapy, it has been demonstrated a significant effect of anti-angiogenic molecules which target mainly the Vascular Endothelial Growth Factor (VEGF) as blocking antibodies. HOWEVER  • their efficiency is stil...

Frequency selective light coupling and decoupling device

The invention concerns a frequency selective light coupling and decoupling device based on a multimode photonic crystal waveguide. If a signal is injected on its fundamental mode, it is converted into a higher-order mode inside the structure. Then, this higher-order mode is outcoupled without perturbing the fundamental mode by thinning to a few rows the lateral photonic crystal cladding on one side (or both sides). The wave leaks as a local plane wave...

Global vision system for laparoscopic surgery

In a laparoscopic surgery, the endoscope and instruments are inserted inside the abdominal wall through small hollow cylinders called trocars. The trocars are equipped with seals that maintain the gas inside the abdominal cavity while instruments are introduced through the abdominal wall. The global vision system is an “augmented trocar” comprising two mini-cameras like the ones that can be found on a cellphone. An extraction and housing system pe...

High throughput screening of lingo ligands: a new drug discovery tool for the treatment of neurodegenerative diseases

The invention relates to a screening method of Lingo’s inhibitors using the monitoring of conformational changes of Lingo-1, 2, 3 or 4 induced by the binding of potential ligands. This technology uses bioluminescence resonance energy transfer (BRET) technology and can be performed on living cells, membranes or cellular extracts in microplates. The BRETs induced by potential ligands are measured on a microplate reader and the assay has been applied t...