Offres de technologies

P42 - preclinical development of p42 peptide

Preclinical development of P42 peptide, orphan drug for Huntington’s disease ContextHuntington’s disease is a genetic and hereditary neurodegenerative disease that results mainly in a profound and severe alteration of a patient’s physical and intell...

Projet p42 - développement pré-clinique du peptide p42

Développement pré-clinique du peptide P42, médicament orphelin contre la maladie de Huntington ContexteLa maladie de Huntington (MH) est une maladie neurodégénérative génétique et héréditaire se traduisant principalement par une altération profonde...

Silexe - extract strategic metals from weee sources

Process to extract strategic metals from weee sources, notably to recycle tantalum from electronic boards ContextTo handle issues related to diminishing natural resources, recycling is emerging as an essential vector for change. Like the rest of Eur...

Silexe - extraction des métaux stratégiques issus des deee

Procédé d’extraction des métaux stratégiques issus des DEEE et notamment la valorisation du tantale à partir de cartes électroniques ContextePour répondre aux enjeux de la raréfaction des ressources, le recyclage apparaît comme un levier incontourna...

Ion ex project - new materials for treating anionic contaminants

Synthesis and implementation of new materials for treating anionic contaminants. These absorbents are highly effective for fixing mineral anions, molecular entities such as certain pesticides, colorants, and active substances, or radionuclides. CONT...

Projet ion ex - nouveaux matériaux pour le traitement des contaminants anioniques

Synthèse et mise en forme de nouveaux matériaux pour le traitement des contaminants anioniques. Ces adsorbants permettent de fixer très efficacement des anions minéraux, des entités moléculaires anioniques comme certains pesticides, des colorants et...

Electrical conductivity measurement clamp for ion exchange membranes

Existing techniques for measuring electrical conductivity of hydrophilic films, as ion exchange membranes (IEM), either work with solutions at low concentrations, or provide hard-to-reproduce measures, or require to take the membrane out of its equil...

Cachemir: personalized medicine, improves response rate to cisplatin in patients with non-small cell lung cancer

The miRNA research field is of interest for the future and is now well established that miRNAs represent new potential therapeutic targets as well as relevant diagnostic / prognostic biomarkers. Nearly 60% of patients with non-small cell lung cancer...

Cachemir: médecine personnalisée augmentant les taux de réponse des traitements des tumeurs pulmonaires à base de cisplatine

L’étude des miRNA montre qu’ils représentent de nouvelles cibles thérapeutiques potentielles ainsi que des biomarqueurs diagnostiques / pronostiques pertinents. Près de 60% des patients atteints du cancer du poumon non à petites cellules sont amenés...

An innovative procedure for preserving cells, tissues or organs in hypothermia

A conservation improves the cells survival and maintains functional capacities of cells, tissues and organs without freezing step. This procedure improves the quality of graft. This procedure involves a pre-incubation of cells, in moderate hypothermia, under an hypoxic and/or hypercapnic atmosphere, before being transferred into strict hypothermia.

Delta-cd20: new biomarker for diagnosis applications

The EFS inventors established a novel CD20 alternative mRNA coding for truncated protein of 15-17 Kda (DELTA-CD20) lacking large parts of the transmembrane segments. This protein is expressed at various levels in malignancies B-cells and is absent in normal B cells isolated from healthy donors. This data show that truncated protein CD20 could be used as a molecular marker for diagnosis, prognostic and monitoring B-cell malignant diseases. Moreover t...

Hla-g: a new molecule for bone resorption treatment

The inventors showed that HLA-G molecule blocks osteoclastogenesis and promotes bone formation. Data suggest that HLA-G isoform can be used for treatment or prevention of bone resorption like osteoporosis.

Injectable solution for cells preservation

Solution which preserves the quality / quantity and the functionality of cells during at least 48 hours at 4°C. Proof of the concept examples: Ex-vivo expanded CD34+ cord blood cells (most vulnerable cells) were stored at 4°C in two media: 4 % of Human Serum Albumin (HAS 4%) and Injectable solution (SEC).

Innovative diagnostic tools for nucleid acid detection based on ultrasensitive polythiol probes

Development of robust polythiol probes which can be efficiently immobilized in a stable way on : • Maleimide-activated microplates (ELOSA) • Electrodes (gold, diamond.....) • Magnetic/micro/nanoparticles These formats are compatible with both optical and electrochemical detection. These innovative molecular tools increased strongly the performances of analytical systems.

Rapid diagnostic test for genotyping

This invention concerns a radid test for the multiplex and visual detection genotyping of PCR products directly amplified from biological samples. This multiplex test allows simultaneous identification of several SNP alleles in a single reaction. This rapid test doesn’t require nucleic acid extraction steps of the biological sample, purification and denaturation of the amplified products. The proof-of-concept was achieved on human erythrocyte antig...

Flexible electrostatic kinetic energy harvester

Our device converts mechanical energy into electricity, when repeatedly pressed and released by an external mechanical action. The device has a sandwich structure, with flexible or solid electrodes on the surface and with an organic electret material...

Colloidal sers substrate

Every type of molecule has a distinct «Raman signature» that can be enhanced by special surfaces called SERS substrates, standing for “Surface Enhanced Raman Spectroscopy”. SERS techniques are useful to detect molecules at very small concentrations (...

Treating life-threatening purpura fulminans

Purpura fulminans (PF) is an uncommon but fatal disorder characterized by rapidly progressive thrombosis with hemorrhagic infarction, disseminated intravascular coagulation and multi-organ failure, which leads to death in 30% of patients and often se...

Méthode d'analyse de l'activité cérébrale

RTConTrack est une méthode d'analyse et de comparaison des processus cognitifs cérébraux explorés en IRM. La méthode d’analyse est basée sur des mesures anatomiques et fonctionnelles réalisées chez les sujets, de façon individuelle, et permet de déterminer avec précision les zones cérébrales impliquées dans la réalisation de tâches cognitives. Cela est possible par la constructio...

Assessment of malignancy and prediction of efficacy of treatment of tumours

The proposed solution is an objective method for prognosis of a cancer based on the analysis of a virtual slide (from a solid tumour specimen) by a software program. Using a machine learning algorithm, 3 patterns emerged from linear quantification of lymphocytes of 117 patients. For example, the relative risk of relapse at 5 years is 16 if you have the pattern 3 (compared to the pattern 1). This technique is more reliable and more rapid than current...

Endoscopic intraluminal device for morbid obesity and diabetes treatment

The technology is an endoscopic intraluminal device implanted temporarily. The structure of the device allows a double action by restricting the quantity ingested (intra gastric balloon effect) and also limiting bolus absorption (duodeno-jejunal bypass liner effect). The device implantation is suitable for ambulatory surgery, which reduces duration of hospitalization and health care costs for patients....

Room of illumination for raman spectroscopy

Analytical Quality Control aims at guaranteeing the parameters, identity, purity and concentration of the molecules of interest. In hospital pharmacies, manufactured products can be expensive or need specific precautions of use (e.g. chemotherapies). In general, the devices used for quality control present many drawbacks in terms of waste of time and materials, of samples loss of integrity or of exposure of medical staff to hazardous compounds. The in...

Composé destiné au traitement des douleurs abdominales fonctionnelles

La technologie proposée est un nouveau traitement des douleurs abdominales fonctionnelles. Il a été démontré que l’utilisation du composé permettrait la prévention et le traitement de ces douleurs chez l’adulte, mais également chez l’enfant. Le produit a déjà été administré à deux enfants qui présentaient ce type de douleur, sans qu’aucun élément pathologique particulier n...

Utilisation du cannabis médical (sativex®) dans la dégénérescence neuronale de l’oesophage (achalasie)

L’achalasie est une dégénérescence inflammatoire neuronale causant des troubles de la motilité de l’oesophage (dysphagie, régurgitations, perte de poids importante). Aucun traitement médicamenteux (myorelaxants) n’a prouvé son efficacité et les alternatives thérapeutiques sont invasives et peu efficaces. Nous proposons une nouvelle indication pour le cannabis médical (Sativex ®) ...

Device for measuring the length of a stenosis

Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) affect around 1.6 million Americans and represent a sales market worth $5.6 billion worldwide. Intestinal inflammation often results in stenosis, for which a classic treatment is surgical resection. However, surgical resection is a drastic option ; if the stenosis is located on a zone accessible to endoscopy, it can be treated alternatively by dilatation, using an endoscope coupled...

Method for increasing the pool of ngn3+ endocrine progenitor cells and pancreatic endocrine cell mass

Controlling glycemia with insulinotherapy is a challenge that diabetic patients face every day. Moreover, insulinotherapy is not a curative therapy by any means. This line of treatment is only palliative and presents many limitations for the fine control of blood sugar levels. Uncontrolled blood sugar levels can result in serious damages to the eyes, nerves and kidneys of diabetic patients. However, pancreatic islets transplantation provides an altern...

New biodegradable anti-migration intestinal stent

In the US, nearly 1,5 million patients suffer from Crohn’s disease. The most common complication is digestive stenosis (50% of patients). If the stenosis measures less than 5 centimeters, an endoscopic dilatation is possible. However, it is associated with relapse rates of 30 to 50 % at 1-3 years. In this case, the patient undergoes another endoscopic dilatation or sometimes a bowel resection. The use of covered expandable metallic prostheses (used...

Endovascular scissors for aortic fenestration

Ciseaux de fenestration endovasculaires

La dissection de l’aorte thoraco-abdominale est une pathologie grave, engageant le pronostic vital des patients à court et long terme. L’incidence est d’environ 1% avec un taux de mortalité de 50% dans les 48 premières heures. Elle se caractérise par une déchirure au niveau de la paroi interne de l’aorte permettant au sang de s’engouffrer entre les feuillets superposés constituant...

Compounds for the treatment of mitochondrial diseases

The present invention relates to the isolation and development of drugs to treat mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as NARP syndrome. NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) is a maternally transmitted hereditary syndrome characterized by retarded development, and accompanied by retinitis pigmentosa (RP), dementia, ataxia, proximal neurological muscle weakness ...

Enabeling/facilitating trans-cutaneous delivery of active material

Efficient trans-cutaneous delivery of active molecules is still a challenge due to the nature itself of the dermal tissue. The permeabibility of therapeutic agents can be improved by permeability agents but most of the induced delivery mechanisms induce irreversible skin alterations. We present here an original strategy consisting in using the active molecule itself to parcicipate into ist own trans-cutaneous transport, while protecting solubilizing a...

Low energy consumption backery oven

Bread baking requires a large quantity of energy – roughly 2 to 5 Mjoules /kg that is 2 to 3 times higher than the energy required for the same mass of a food product in the form of canned food for example. Furthermore food habits are changing in the world : we see in most European countries a decreasing consumption of bakery products at home while the consumption of bakery products outside home increases significantly. This market trend is suppor...

Nanpoparticles synthesis

Nanopowders are of great interest due to their specific properties. There are various production routes but quality of the powders ie composition, size and size distribution, crystallography… may vary from one another.

Natural compounds activating sirt1 for the cellulite treatment

The sirtuin family concerns nuclear NAD+ dependant deacetylases, playing an important role in deacetylation of histones. Sirtuin 1 is the best known situin. It is involved in an important number of metabolic processes. It has several target as p53, FoxO, PPAR gamma, PGC1 alpha, UCP2, LXR and Ku70, key regulating proteins in cell functions. Sirt1 has a global anti-aging effect. The Sirt1 expression decreases along the lifetime. Sirt1 has also a rol...

One step in-situ graphene oxide reduction in composite

It is well known that electrical or thermal properties of graphene are of importance in composites for applications like anti-static composites, biomedical, organic electronics, sensors… but the mixing of graphene in polymers is not easy. It has thus been proposed to mix graphene oxide (GO), a graphene derivative which by contrast to neat graphene can be easily processed, with the organic matrix and then to reduce it. This reduction step is performe...