Offres de technologies

Photoactivation process of copper-radical oxidase enzymes (cros)

The BBF (Biodiversité et Biotechnologie Fongiques) team in collaboration with the iSm2 (Institut des Sciences Moléculaires de Marseille) team has developed a new activation process of copper-radical oxidases (CRO). These enzymes enabled to obtain aldehydes (products with multiple industrial applications) and the reusable coproduct H2O2, in an environmentally friendly context, at a low cost and with an innovative and non-invasive approach....

Procédé de photo-activation des enzymes oxydases à cuivre-radical (cros)

Les équipes de l’UMR 1163 BBF (Biodiversité et Biotechnologie Fongiques) en collaboration avec l’UMR 7313 iSm2 (Institut des Sciences Moléculaires de Marseille) ont développé un nouveau procédé d'activation des oxydases à cuivre-radical (CRO), qui permettent d'obtenir des aldéhydes (produits ayant de multiples applications industrielles) ainsi que le coproduit H2O2 réutilisable, dans...

Production of agromaterials by bioextrusion of a solid lignocellulosic material seeded with fungal biomass

The LCA (Laboratoire de Chimie-Agro-Industrielle), BBF (Biodiversité and Biotechnologie Fongique) and CRT CATAR teams have developed, through the twin-screw extruder, a process for using binding properties of filamentous fungi to produce agro-materials from lignocellulosic substrates. This process provides a controlled destructuring of lignocellulose by jointly promoting its inoculation with a mycelial suspension to obtain massive and homogeneous fu...

Production d’agromatériaux via bioextrusion matière lignocellulosique solide ensemencée avec biomasse fongique

Les équipes des laboratoires LCA (Laboratoire de Chimie Agro industrielle), BBF (Biodiversité et Biotechnologie Fongiques) et du CRT CATAR ont développé, par l’intermédiaire de l’ extrudeur bi-vis, un procédé permettant d’utiliser les propriétés liantes des champignons filamenteux pour produire des agromatériaux à partir de substrats lignocellulosiques. Ce procédé permet d’ob...

Endoquant: innovative direct assay of total endotoxins

CONTEXT Contamination by bacterial endotoxins causes a multitude of disorders depending on the affected area, and can lead to sepsis, a systemic inflammatory response syndrome with a mortality rate of about 30%. Thus, the detection of these endotoxi...

Endoquant : méthode innovante de dosage direct des endotoxines

CONTEXTE Une contamination par des endotoxines bactériennes provoque une multitudes d'affections selon la zone touchées, et peut déboucher sur un sepsis, réponse inflammatoire généralisée au taux de mortalité d’environ 30%. La détection de ces endot...

Modulation of tnf-tnfr2 to promote alloreactivity and anti-leukemia response during blood malignancy relapse

Blood malignancy such as chronic myeloid leukemia (CML) and lymphomas are pathologies dealing with a high relapse rate. Allogeneic hematopoietic stem cell transplantation (Allo-HCT) and Donor lymphocyte injections (DLI) are among potential strategies...

Novel combination of 2 anti-metabolic drugs for the treatment of diffuse large b-cell lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma in adults. Even though cure rates have significantly improved in the last few years since the introduction of new immunochemotherapy treatments, refractory/ relapse cases can reach up...

Cq mat - quality control and non-destructive testing of metallic materials by electronic transport

CONTEXT Non-Destructive Testing (NDT) brings together all the techniques and processes capable of providing information on the health of a part or a structure without resulting in alterations detrimental to their subsequent use (no sampling of 'samp...

Cq mat - contrôle qualité et contrôle non destructif de matériaux métalliques par transport électronique

CONTEXTE Le Contrôle Non Destructif (CND) regroupe l’ensemble des techniques et procédés aptes à fournir des informations sur la santé d’une pièce ou d’une structure sans qu’il en résulte des altérations préjudiciables à leur utilisation ultérieure...

Rac - method of handling a robot with 4 autonomous cables

CONTEXT There are devices for positioning platforms suspended by gravity and movable in three-dimensional spaces with 6 degrees of freedom by means of at least 6 cables. The cables can in particular be parallel two by two, or else distributed in th...

Rac - procédé de manipulation d'un robot à 4 câbles autonomes

CONTEXTE Il existe des dispositifs de positionnement de plateformes suspendues par gravité et déplaçables dans des espaces en trois dimensions selon 6 degrés de liberté au moyen d’au moins 6 câbles. Les câbles peuvent notamment être parallèles deux...

Serie2graph

Automatically determine the health of a system, equipped with sensors, by detecting and graphically represent subsequence anomalies in a time series, without prior knowledge of the system. Applications: Internet of Things Operation monitoring: a...

Guidevac

Customized and personalized indoor guidance and localization of crowds or individuals, inside a building, for either evacuation or sheltering (during emergency situation) or the best routes to reach spots of interest (Indoor locationbased services, f...

A simple molecular assay for rhd genotyping

Rhesus (Rh) status is routinely determined by serological analyses, but molecular analysis of the RHD gene for phenotype prediction is required when discrepancy and/or ambiguity occurs. EFS has identified a novel predominant RHD allele resulting in the weak D phenotype in the Indian population. A new RHD genotyping method based on the detection of this novel allele is proposed. APPLICATIONS: • Identification of the most prevalent weak D variant ...

An innovative approach for multiple myeloma treatment

Multiple myeloma (MM) is the second most prevalent hematological cancer after non Hodgkin’s lymphoma (10-12%) and is responsible for 2% of cancer death. In MM, the bone marrow microenvironment (constituted by mesenchymal stromal cells, “MSC") is pivotal to the establishment and progression of the pathology and MM plasma cell growth. MM-MSC are abnormal and overexpress Toll like receptor 4 (TLR 4). EFS researchers have found that TLR 4 is ove...

An innovative approach for the treatment and prevention of graft versus host disease and cytokine release syndrome

The curative efficacy of allogeneic hematopoietic cells transplantation is considerably reduced by Graft versus Host Disease ( GvHD ) which causes significant mortality and morbidity. GvHD represents a pathology for which immunosuppression approaches like corticosteroids remain to this day the first line of treatment. However, the corticosteroid therapy is associated with many iatrogenic complications and the prognosis of GvHD is poor in case of no...

An innovative procedure for preserving cells, tissues or organs in hypothermia

A conservation procedure which improves the cell survival and maintains functional capacities of cells, tissues and organs without freezing step. This procedure improves the quality of graft. This procedure involves a pre incubation of cells, in moderate hypothermia, under an hypoxic and/or hypercapnic atmosphere, before being transferred into strict hypothermia. APPLICATIONS: • Short to mid term cells preservation • Storage and transport of...

Injectable solution for cell preservation

Hematopoietic stem and progenitors cells cannot be preserved for long time at +4°C. They are especially vulnerable after ex vivo expansion. Before injection to the patient, these cells are usually resuspended in human serum albumin solution, which does not ensure their conservation over several hours. It is possible to preserve hematopoietic cells at +4°C without freezing by more complex media, which are, however, not injectable. The EFS proposes...

Innovative diagnostic tools for nucleic acid detection based on ultrasensitive polythiol probes

Despite considerable advances over the last years in diagnostic, innovative diagnostic system allowing a sensitive, specific, fast and multiplex detection of nucleic acids are still needed. In this context, the development of new diagnostic technologies with high performances appears to be a challenge. The EFS TransDiag Laboratory developed innovative diagnostic tool with very high performances dedicated to rapid analysis of genomes. APPLICATIONS: ...

Process for obtaining human brown/beige adipocytes

Over one billion adults are either overweight or obese and more than 150 million adults have diabetes. Adipose tissues play an important role in obesity, insulin resistance and diabetes. White Adipose Tissue (WAT) is the primary site of depot of triglycerides and release of fatty acids. Brown Adipose Tissue (BAT) is specialized in thermogenic energy expenditure through the expression of uncoupling protein 1 (UCP 1). Recently, a third type of ful...

Rapid diagnostic test for genotyping

The French Blood Establishment laboratory has developed an innovative diagnostic test based on visual detection of multiplex PCR amplicons, for the identification of Single Nucleotide Polymorphisms (SNP) in biological samples. APPLICATIONS: • Diagnostic and therapeutic management: genotyping of SNPs associated with : Pathologies / Predisposition to pathologies / Pathologies severity /Therapeutic response of the patient / Blood group typing • ...

Electrotate - système d’électrochimie à électrodes mobiles

CONTEXTE Le projet s’intègre dans le traitement d’effluents par un procédé d’oxydation avancé. D’ici 2024, les technologies UV & AOP représenteront un tiers du marché total des systèmes de désinfection de l'eau et des eaux usées. Leur développement...

Exfograp - procédé d’exfoliation et fonctionnalisation de graphène en phase liquide par plasma

CONTEXTE Le graphène fait l’objet de perspectives innovantes dans de nombreux domaines d’applications, ceci depuis de nombreuses années. L’effort de Recherche reste très soutenu au niveau international pour répondre à l’attende du marché industriel...

Biocapteur pour la sélection et le suivi en temps réel de multiple marqueurs

CONTEXTE Les biocapteurs portables sont couramment utilisés, que ce soit pour le suivi du diabète, les tests de grossesses, les soins d’urgences ou les analyses environnementales. Cependant les technologies actuelles ne permettent pas de détecter ou...

Micro-pump health: mems micro pump without chamber nor valves

Innovation Membrane micro pump, piloted by electromagnetic control Results The micro device creates a flow without pumping chamber nor valves, The flow is created by the oscillations of a flexible polymer membrane Oscillations are driven b...

Outil de prévention du risque de collision en radiothérapie

CONTEXTE Les machines de radiothérapie sont des installations lourdes fonctionnant en rotation autour du patient placé sur une table de traitement. L’ensemble des déplacements mécaniques de la machine et de la table de traitement nécessaires à la ré...

Diagnosis and/or prognosis of her2+ cancers using moesin as a biomarker

About 25% of primary human breast cancers are due to the deregulated expression of ErbB2/HER2. HER2- targeted therapies have improved patient survival, but both de novo and acquired resistance remain a challenge, as only 25% of treated patients respo...

Diagnosis and/or prognosis of her2+ cancer using one or more mirna as biomarkers

About 25% of primary human breast cancers are due to the deregulated expression of ErbB2/HER2. HER2-targeted therapies have improved patient survival, but both de novo and acquired resistance remain a challenge, as only 25% of treated patients respon...

New nanoparticles with targeted expression vector as a therapeutic approach for idiopathic nephrotic syndrome

Idiopathic Nephrotic Syndrome (INS) accounts for 85% of glomerular nephropathies in children and 25-30% of those in adults. Pathogenesis of this syndrome is based on an immune disorder whose mechanism remains incompletely understood. The team has ide...

Bioprocédé d'élimination du sulfite dans le vin

CONTEXTE Les sulfites sont des composés chimiques très employés par la filière viti vinicole pour leurs propriétés antioxydantes et antiseptiques très fonctionnelles. Toutefois, il est capital que les sulfites soient utilisés judicieusement et avec...

Specape: dispositif d’évaluation d’épaisseur d’un revêtement par thermographie infrarouge

L'innovation: • Mise au point d’un dispositif embarqué permettant d’évaluer l’épaisseur d’un revêtement sur un échantillon à partir d’images de thermographie infrarouge, et utilisant un réseau de neurones hybride. Résultats• Algorithmes développés...

Crop pathogens quantification

Innovation                      •Quantitative multiplex PCR-based analysis method•High-speed and less expensive method•Tool for measuring the health status of a sample (plants, soil) at a given time ResultsDevelopment of the high-speed qPCR quantif...

Q-pac: quantification des pathogènes des cultures

L’innovation • Méthode d'analyse par PCR Quantitative multiplex, à haut-débit et moins chère • Outil de mesure de l'état sanitaire d'un échantillon (plantes, sol) à un instant t. Résultats Le développement de la méthode de quantification haut déb...

Yest: nouvelles macromolécules à fort pouvoir moussant pour l’agroalimentaire

L’innovationNouvelles macromolécules de type colloïdes à fort pouvoir moussant et épaississant, produites par des levures RésultatsApplication oenologique:Mousse deux fois plus abondante, avec une forte stabilité dans le temps, par rapport aux compo...

Topix: ai-based solution allowing to summarize massive databases involving text written by users on products

The AI-based solution produces a simultaneous clustering (co-clustering) of users and products, based on the key emerging topics from the reviews and by the underlying model. The typical use case consists in an e-commerce company interested in unders...