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- TRL (Technology readiness level) -
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- Titre Innovative diagnostic tools for nucleid acid detection based on ultrasensitive polythiol probes
- Description Development of robust polythiol probes which can be efficiently immobilized in a stable way on :
• Maleimide-activated microplates (ELOSA)
• Electrodes (gold, diamond.....)
• Magnetic/micro/nanoparticles
These formats are compatible with both optical and electrochemical detection. These innovative molecular tools increased strongly the performances of analytical systems.
- Bénéfices • Diagnostic : biological analysis and R&D
• Quality control :
∙ Environment : freshwater, sewage
∙ Security : freshwater, epidemic survey
∙ Industrial process : food, pharmaceutical, cosmetic industries
- Nouveauté • Robust molecular tool can be integrated in any kind of diagnostic platforms (optical and electrochemical) depending on targeted needs
• Targets: detection of short/ long synthetic or natural amplified sequences
• Ultrasensitive detection: 10 pM for optical detection and 10 fM for
electrochemical detection
• High specificity: DNA screening or sequencing
• Multiplex: able to detect several nucleic acid sequences in parallel
- Mots clés Innovative diagnostic, polythiol probes, genotyping or screening, optical or electrochemical detection (Enzyme-Linked OligoSorbent Assay ELOSA, sensors...).
- Secteurs Health
