-
- TRL (Technology readiness level) -
-
- Titre Implementation of alternating langmuir and anti-langmuir zones in chromatography columns
- Description The core of the invention is to alternate Langmuir and Anti-Langmuir zones along the column so that the steeper concentration front is periodically moving up- and downstream the center of the peak (in an accordion fashion), thereby limiting overloarding dispersion.
Two different types of stationary phases with respectively L and AL adsorption properties have to be incorporated in the column alternatively in space to achieve this effect. Simulations have indicated that an increase in performance by a factor of 2 can be obtained.
Such a decreasing in dispersion allows to generate much higher concentrations and purity of the separated streams.
- Bénéfices - Separation and purification with higher final concentration
- Higher throughput for preparative separation
Potential applications :
- Pharmaceutical industry
- Biotechnology
- Food-water-environmental control
- Nouveauté
- Mots clés Preparative chromatography, HPLC, Concentration overloading, Dispersion minimization, Plug flow reactor
- Secteurs Chemicals, Materials & plant-based materials Environment & Construction Health
