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- TRL (Technology readiness level) -
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- Titre Enabeling/facilitating trans-cutaneous delivery of active material
- Description Efficient trans-cutaneous delivery of active molecules is still a challenge due to the nature itself of the dermal tissue. The permeabibility of therapeutic agents can be improved by permeability agents but most of the induced delivery mechanisms induce irreversible skin alterations. We present here an original strategy consisting in using the active molecule itself to parcicipate into ist own trans-cutaneous transport, while protecting solubilizing and delivering it to its active site.
- Bénéfices This invention has applications in formulations, in terms of solubilization, protection, conveyance and transcutaneous diffusion of an active principle, wherein the amphiphilic molecule can also play the role of permeabilization agent for transcutaneous conveyance. These formulations, which are simplified and harmless to the skin, thus make it possible to increase the principle active concentration in the skin and to promote its passage through the stratum corneum.
- Nouveauté The invention thus proposes to associate a biocompatible amphiphilic acidic transporter with an active principle comprising one or more basic functional groups. This intermolecular association leads to a novel amphiphilic species corresponding to the formation of an acid/base pair bound by electrostatic interactions and stabilized by Van der Waals interactions between the hydrophobic moieties of the two components. The amphiphilic complex thus formed by association can lead, according to its concentration in water as well as the nature of the active principle (volume, hydrophobicity), to a group of self-assembled structures such as micelles or vesicles. The objects thus formed can also be used for self-transport of the active principle.…
- Mots clés Trans-cutaneous delivery, amphiphilic species, vesicle, micelle
- Secteurs Consumer Goods Health
